|
Matti Airaksinen |
Research topics: In vivo roles of neurotrophic factors, inhibitory transmission and novel neuronal LRR proteins Methods: Molecular and cell biology methods, behavioral, biochemical and histological analysis of GM mice |
| Urmas Arumäe University of Helsinki, Institute of Biotechnology |
Research topics: Molecular and cellular mechanisms of programmed death in the neurons that are controlled by the neurotrophic factors. Methods: Dissociated or organotypic cultures of the neurons, treated with or deprived of the neurotrophic factors, and transfected with techniques such as direct microinjection, viral transfection etc. |
|
Marc Baumann |
Research topics: Molecular mechanisms of neuronal death Methods: Culture of neuronal cells, primary neurons and brain slices, |
|
Synnöve Carlson |
Research topics: Neurophysiological mechanisms of attention and memory Methods: Extracellular single cell recordings; |
|
Eero Castrén |
Research topics: Physiological and pathological effects of neurotrophic factors and centrally active drugs in brain Methods: Behaviroural and biochemical analysis of transgenic mouse models; Culture of primary neurons and brain slices; Transfections with plasmid and virus vectors; Analysis of gene expression by DNA |
|
Eleanor Coffey and |
Research topics: The project aims to determine the roles and regulation of the multifunctional JNK stress-activated protein kinase pathway in neurons of the brain. This information is required for the development of selective approaches to manipulating undesirable consequences of JNK action such as neuronal apoptosis. Methods: Kinase protein chemistry, real-time fluorescence microscopy, mutagenesis, transgenic mice, expression of recombinants and proteomic approaches. |
|
Kristian Donner |
Research topics: Information processing in the visual system: mechanisms and limitations Methods: Electrophysiology (suction pipette technique, extracellular recordings, electroretinogram), Microspectrophotometry; Fluorometry; Quantitative behavioural tests on frogs; Visual psychophysics on humans |
| Adrian Goldman University of Helsinki, Institute of Biotechnology |
Research topics: Studies of membrane integral and associated-proteins, with a particular focus on proteins important in neuroscience, such as the GDNF-GFRα-RET signaling system, and potassium/chloride cotransporters Methods: X-ray crystallographic and biochemical methods |
|
Riitta Hari |
Research topics: Systems neuroscience and human brain imaging in health and disease Methods: Magnetoencephalography (MEG); Electroencephalography (EEG); Magnetic resonance imaging (MRI); Functional magnetic resonance imaging (fMRI); Diffusion tensor imaging (DTI); Psychophysics; Eye gaze tracking |
|
Irma Holopainen |
Research topics: Molecular mechanisms of seizure-induced neuronal damage in the developing hippocampus Methods: Cultures of hippocampal slices and primary neurons, Immunocytochemistry, In situ hybridization, Western blotting, electrophysiology of brain slices |
|
Kai Kaila |
Research topics: Neuronal development, plasticity and hyperexcitability: biophysical, molecular and cellular mechanisms Methods: Electrophysiology (intra- and extracellular recordings; ion-selective microelectrodes; EEG); Microfluorescence imaging; |
| Hasse Karlsson University of Helsinki, Institute of Clinical Medicine, Department of Psychiatry |
Reseach topics: Functional brain imaging in psychiatry, recently neurodevelopment Methods: PET, fMRI |
|
Kari Keinänen |
Research topics: Molecular analysis of ionotropic glutamate receptors. Methods: Recombinant protein expression and purification. Ligand binding studies. |
|
Leonard Khirug |
Reseach topics: Functional and morphological plasticity of tripartite synapse. Methods:Brain slices, cultured neurons, confocal and multiphoton microscopy combined with patch clamp, local photolysis of caged compounds, calcium imaging, total internal reflection fluorescence (TIRF) microscopy. |
|
Esa Korpi |
Research topics: Pharmacology of GABAA receptors. Methods: Ligand and in situ hybridization autoradiography, molecular biology, behavioral phenotyping and pharmacology, electrophysiology of brain slices, cultured neurons and Xenopus oocytes |
|
Anna-Elina Lehesjoki |
Research topics: Mechanisms of Brain Disease: From Gene Mutation to Molecular Pathogenesis in Inherited Disorders Methods: Molecular genetics techniques, cellular and animal models, histological methods and magnetic imaging. |
|
Dan Lindholm |
Research topics: Characterization of the pathophysiology and mechanisms of neurodegenerative diseases. Study of neural stem cells (NSC) by analysing factors influencing cell proliferation, differentiation and plasticity of these cells in vivo and in vitro. Methods: Molecular, biochemical and cell biology methods, proteomics, transgenic animals, monoclonal antibodies. |
|
Pertti Panula |
Research topics: Histaminergic Regulation of Brain Functions Methods: Confocal and multiphoton imaging |
|
Juha Partanen |
Research topics: Fibroblast growth factor signaling in embryonic development Methods: Molecular, histological and cell biology methods, transgenic animals |
|
Ulla Pirvola |
Reseach topics: The inner ear – from development to therapeutic applications Methods: Molecular, histological and cell biology methods, transgenic animals, organotypic cultures, viral-mediated gene transfer |
|
Asla Pitkänen |
Research topics: Molecular basis of epilepsy Methods: Antero- and retrograde neuronal tracing; 3D reconstruction of biocytin filled neurons; Unbiased stereological cell counting; Confocal and electron microscopy; Slice electrophysiology; Long-term video-EEG monitoring of epileptogenesis and epilepsy; Single cell RT-PCR; Molecular profiling with cDNA arrays |
|
Heikki Rauvala |
Research topics: Extracellular matrix associated molecules in the development, disorder and regulation of the nervous system Methods: Molecular and cell biology methods |
|
Juha Rinne |
Research topics: Etiology, pathophysiology and treatment of neurodegenerative diseases and normal ageing. Cognitive activation studies concerning memory and language functions. Methods: Clinical, neuropsychological and brain imaging technigues (PET and MRI) |
| Claudio Rivera University of Helsinki, Neuroscience Center |
Research topics: The focus our research group is on the interplay between neurotrophic factors and inhibitory neurotransmission Methods: Primary and slice neuronal cultures, radioactive and fluorescent double in situ hybridization, 64-channel extracellular recordings of acute and cultures neurons as well as basic electrophysiologycal recording techniques |
|
Mart Saarma |
Research topics: Neurotrophins and their receptors in differentiation, their gene structure and regulation of expression Methods: Molecular biology methods (SDS-PAGE, isoelectric focusing, 2-Dimentional gel electrophoresis etc.) |
|
Riitta Salmelin |
Reseach topics: Language perception and production; neural connectivity Methods: Magnetoencephalography (MEG); Electroencephalography (EEG); Magnetic resonance imaging (MRI); Functional magnetic resonance imaging (fMRI); Diffusion tensor imaging (DTI); Psychophysics; Eye gaze tracking |
|
Mikko Sams and |
Research topics: Neurocognitive mechanisms of multisensory information processing Methods: Electroencephalography (EEG); Magnetoencephalography (MEG); |
|
Tarja Stenberg |
Research topics: Effects of sleep loss on the brain, the cellular and molecular mechanisms during sleep, and the basic mechanisms underlying some clinical sleep disturbances Methods: Polysomnography (human and rodent); In vivo microdialysis; HPLC measurement of several neurotransmitters; In situ hybridization; Radioimmunoassays, ELISA; Immunohistochemistry |
|
Tomi Taira and |
Research topics: Mechanisms of synaptic plasticity in the adult and developing brain Methods: Electrophysiological techniques (extra- and intracellular recordings), molecule and cell biological techniques, imaging |
|
Heikki Tanila |
Research topics: Brain mechanisms of memory. Neuro-physiological correlates of age-associated memory impairment. Hippocampus and the prefrontal cortex Methods: Behavioral assessment of learning and memory in rats and mice. Behavioral screening of transgenic mice. Electrophysiological recordings in freely moving rodents. Induction and recording of hippocampal LTP in vivo and in vitro. In vivo microdialysis, HPLC, ELISA |
|
Simo Vanni |
Research topics: Early phase of visual processing, relation between measured imaging signals, visual behaviour, and biological image analysis Methods: Electroencephalography (EEG); Magnetic resonance imaging (MRI); Eye tracking and Functional MRI (fMRI); Head coils; Galvanic skin response (GSR); Magnetoencephalography (MEG) |
|
Juha Voipio |
Research topics: The biophysical mechanisms of synaptic and non-synaptic transmission in the mammalian brain Methods: Electrophysiology (intra- and extracellular recordings; ion-selective microelectrodes; EEG); |
|
Matti Weckström |
Research topics: Cell and membrane biophysics: graded potential neurons in insects, and cardiac muscle cells in mammals Methods: Intra-cellular and patch-clamp recordings, single-electrode voltage clamp, linear and nonlinear system analysis, fluorometry and fluorecence imaging, tissue perfusion, molecular biology |
|
Garry Wong |
Research topics: Role of small RNAs in Neurodegeneration. Phenotypes and genotypes of Parkinson's disease models in C. elegans. Methods: Microarrays, Bioinformatics, C. elegans. |
|
Karl Åkerman |
Research topics: Activation mechanisms and properties of Ca2+ influx pathways activated by GPCRs Methods: Fluorescence imaging techniques; Ca2+ measurements, confocal, and 2D Ca2+ imaging, dual wavelength cuvette and 96 well measurements; Combined patch clamp and Ca2+ recordings; Reconstitution of signal pathways using the baculovirus expression vector system; Recombinant expression systems; Second messenger measurements; G-protein activation measurements |
Group list
Sivuston toteutus: Yliopistopaino
